For 20 years, our strategy has been consistent – identify and invest in the most promising healthcare ventures led by remarkable and inspired management teams.
We do more than just invest in innovative companies. We establish a partnership with our portfolio companies. The relationship continues beyond the final exit. Members of the SV team are actively involved in the development and/or growth of each portfolio company. We always serve as active board members. We collaborate with management teams to minimize risk and maximize the value of the business, using cash in the most effective way and participate in exit discussions for the benefit of management and investors.
Here’s how we contribute:
Board of Directors
- Provide leadership on the company’s board of directors and various sub‐committees
- Support and guide the management team from entry to exit
- Recruit additional key hires to senior management and independent board members
- Assist in the procurement of supplemental debt and equity capital
- Support, shape and review the business plan, budgets and strategic direction
- Identify corporate, product and technology acquisition targets, and partnerships
- Provide access to an international network of leading experts and key opinion leaders with specific domain knowledge
- Convey understanding of consumer behavior as well as physician and patient needs
- Impart knowledge of legislative initiatives and regulatory approval processes
Deal Structure, Business Plan and Exit Strategies
- Assist with pragmatic milestone-based business plans to promote focus and ROI
- Establish contingency plans (e.g., identify merger opportunities for growth)
- Identify likely corporate investors/acquirers and build toward a successful exit
- Grow industry leading companies that are bought, not sold
We invest in novel science, and we seek breakthroughs – truly innovative medicines, platform technologies, and diagnostics that have the potential to change the practice of medicine.
Adimab, LLC has developed a fully integrated platform for antibody discovery and manufacturing which offers customers/ acquirers a very rapid, 2-3 month path from target to optimized antibody while eliminating most, if not all, third party royalties.Visit website
Development of Monoclonal Antibodies to target infectious diseases.Visit website
Artios Pharma Ltd was established in May 2016 to build an innovative DNA Damage Response (DDR) target pipeline with the potential to transform cancer therapy.Visit website
Focused on preclinical exploration and development of potential treatments for people with hearing disorders, including noise-induced hearing loss or tinnitus.Visit website
Avitide provides an industry-leading custom affinity purification discovery service. The Avitide platform discovers and optimizes selective affinity ligands specific towards customer’s targets for use as bioprocess purification resins in a matter of 4-6 weeks. Avitide’s proprietary affinity ligands are implemented across an array of industry-accepted resins for selective and scalable chromatographic separations.Visit website
AVROBIO, Inc., a leader in lentiviral-based gene therapies, is a clinical stage company developing transformative, life-changing therapies that have the potential to transform patients’ lives in a single dose. The Company is focused on the development of its Phase 1 programs in Fabry disease and acute myeloid leukemia (AML), while actively building a pipeline of therapies to treat other rare diseases, and solid and liquid cancers.Visit website
Developing a platform technology that may enable the creation of a new generation of biotherapeutics.Visit website
Developing therapeutics of the treatment of inflammatory and metabolic diseases.Visit website
A clinical-stage oncology company focused on developing kinase inhibitors for the treatment of cancers.Visit website
Alba based in Baltimore, MD, is focused on the development and commercialization of pharmaceuticals for the treatment of inflammatory and immune mediated diseases. Alba's technology provides the ability to transiently open or close internal barriers such as the intestinal mucosa. Alba is applying its technology to develop treatments for celiac disease and other autoimmune conditions.Visit website
Dedicated to developing and commercializing pharmaceuticals for the treatment of diabetes and related metabolic disorders.
Spin out from GSK. Focused on the development of novel analgesics with commercially attractive efficacy, responder-rate and side effect profiles
Will leverage novel insights into the expression of human endogenous retroviruses in different cancers to develop a pipeline of first-in-class cancer vaccines.
Kesios Therapeutics Limited
Developed novel therapeutics for the treatment of multiple myeloma and other cancers.
Sitryx Therapeutics Limited
Will leverage metabolic insights into the fumarate/fumarate hydratase (F/FH) drug target/pathway to develop a pipeline of first-in-class small molecule drugs to treat a broad range of orphan and blockbuster indications, starting with cancer.
Sutro Biopharma, Inc.
Sutro Biopharma's mission is to enable the production of low-cost, high quality rapidly developed protein pharmaceuticals and innovative vaccines that cannot be manufactured by existing technologies. Previously known as Fundamental Applied Biology's (FAB).Visit website
(NASDAQ: ACHN). Achillion, based in New Haven, CT, is focused on the discovery, development and commercialization of innovative small molecule therapeutics for the treatment and/or prevention of serious infections associated with drug resistant viruses or bacteria.Visit website
Aderis Pharmaceuticals was a Cardiovascular, renal and neurological disease focused therapeutics company dedicated to making a significant difference to people living with cardiovascular, renal and neurological diseases.
Affibody is a biotech company that uses unique affinity ligands to develop products for molecular imaging, targeted therapy and biotechnology applications. The lead product is a Her2 affibody for clinical imaging in breast cancer, and its pipeline includes other oncology imaging affibodies. In addition, affibodies are sold as research reagents and for use in protein separations.Visit website
Affinium Pharmaceuticals, Inc. is a pharmaceutical company focused on the discovery, development and commercialization of novel anti-infective medicines stemming from the bacterial fatty acid synthesis pathway.
Allocure is a biotechnology company at the forefront of innovative cell therapies for the treatment of Acute Renal Failure (ARF).
Allos Therapeutics was developing and commercializing innovative small molecule therapeutics for the treatment of cancer.
Antiva (Vantia Spin-Out)
Spin-Out of Vantia Therapeutics.
Avant Immunotherapeutics, Inc.
Avera focused on the development of small molecule drugs for the treatment of diseases affecting the central nervous system (CNS). Key programs are Alzheimer's disease, schizophrenia associated cognition deficits, IBS, and OAB, and developing an ultra-short acting anaesthesia compound.
Axys developed a protease-inhibitor based products for cancer & inflammatory diseases.
Celldex merged with the quoted company Avant Immunotherapeutics (ticker:'AVAN') in March 2008. Celldex, formerly a wholly owned subsidiary of Medarex Inc., merged with Lorantis Ltd in 2005. Celldex pursues immunological approaches to the treatment of cancers, infectious disease and immunological disorders.Visit website
Cellzome is a drug discovery company building a R&D pipeline in chronic diseases by leveraging its unique drug proteomics engine. The business is based in Heidelberg, Germany and Cambridge, UK.
Cognis is a global supplier of innovative speciality chemicals for the cosmetics, detergents and cleaners industries and nutrional ingredients to the food and healthcare markets.
Dynogen is a neuroscience-based company focused on genito-urinary (GU) and gastro-intestinal (GI) disorders. The company is using its knowledge of neurology and GU/GI disorders to build a pipeline of clinical candidates.
Sold to Alcan in September 2009. ESBATech is a preclinical stage drug discovery company that intends to refocus the business to build a world class Ophthalmology company on the back of an attractive, proprietary antibody fragment platform which can deliver uniquely stable, soluble and monomeric fragments and compelling data on penetration of these fragments into the eye following topical treatment.Visit website
Eyetech was bought by OSI Pharmaceuticals after our exit through public markets. Opthalmolological drug development.
Sold to Merck in May 2006. GlycoFi was a production and engineering of therapeutics proteins.
Gyros, located in Uppsala, Sweden, has developed a proprietary microfluidics technology for processing and analysis of proteins and blood samples. Laboratory processes are integrated into a client specific disc (CD) format. The CD is processed and its contents analysed on software controlled instrumentation.Visit website
ITI is a specialty pharmaceutical company focused on developing innovative, nasally delivered pharmaceutical products with a particular focus on drugs treating pain and CNS-related disorders for which there is proven, unmet patient need.
Functional genomics Acquired by Incyte Pharmaceuticals in September 1999.
Ingenium was a functional genomics and drug development company.
Itero is an early stage company focused on the development and commercialization of differentiated biosimilar and second generation protein products that serve niche markets.
KuDOS was an oncology drug development company. Acquired by Astra Zeneca in December 2005.
LeukoSite was a treatment of Inflammatory diseases and cancer. Acquired by Amgen in October 1999.
Link Medicine is a clinical stage company spun out of Harvard University working on disease-modifying therapies for neurodegenerative diseases.
Lux is developing drugs for ophthalmic diseases. Their lead product is LX211, an oral drug for the treatment of uveitis.
Metris is a women's healthcare company that is developing drugs for the treatment of chronic gynecological and menstrual conditions.
Mpex based in San Diego, CA, is focused on the discovery and development of new-antibacterial drugs that meet the growing clinical need created by multi-drug resistant bacteria. Mpex has identified several approaches to increase the effectiveness of existing antibiotics and decrease the incidence of drug resistance to these antibiotics. Mpex's first product will be an inhaled antibiotic for serious lung infections.
Neurotech based in Lincoln, RI, has developed an encapsulated cell therapy for the delivery of therapeutic proteins in retinal diseases. The first product is ciliary neurothrophic factor (CNTF) for retinitis pigmentosa and age-related macular degeneration (geographic atrophy).Visit website
Oncoethix SA is a private Swiss company focused on developing a portfolio of three to five promising new drugs for cancer treatment. The company intends to develop its compounds through clinical proof of concept and the identification of an expedited registration strategy, after which pharmaceutical partners will be sought to fund pivotal trials and handle commercialization.
Sold to Pfizer in October 2006. PowderMed developed therapeutic DNA vaccines in the areas of chronic viral diseases and cancer.
Quantum Dot developed nanocrystal biological reagents.
Sold to J&J in June 2010. RespiVert is a discovery company focused on Chronic obstructive pulmonary disease ('COPD') and severe asthma. The company's goal is to develop novel inhaled and intranasal drugs for respiratory disorders with high unmet medical need and high commercial potential based on novel insights on biology and chemistry.
Sold to Pfizer in April 2006. Rinat developed proteins for the treatment of diseases and disorders of the nervous system.
Acquired by Helsinn in February 2009. Helsinn is developing small molecule drugs based on the biology of ghrelin,a gut peptide known to stimulate appetite. The lead compound is in Ph II for cancer cachexia; a second compound has completed an initial clinical study and is moving toward Ph II for post-operative ileus. Additional indications are being explored for follow-on compounds. Formerly known as Rejuvenon.
Sold to Illumina ILMN. Solexa used ultra high throughput DNA sequencing.
Third Wave Technologies
Third Wave developed products for analysing genetic variations.
Trine, formerly Essential Therapeutics Inc., in-licenses, develops and plans to commercialize new classes of pharmaceutical products focused on renal, metabolic and GI clinical areas.
Versicor was a drug development company for infectious diseases (Changed name to Vicurion Pharmaceuticals in 2003)
X2-Pharma is a biopharmaceutical company dedicated to the discovery and development of small molecule pharmaceuticals for the treatment of inflammatory diseases.
We target compelling teams and differentiated technologies that address major, unmet clinical needs – disrupting cost, relieving the symptomatic burdens of illness, and improving quality of life.
AcuFocus, based in Irvine, CA, is developing an implantable corneal in-lay for the correction of presbyopia.Visit website
Carnation™ P-Wave centric arrhythmia monitoring.™Visit website
CardioFocus is based in Marlborough, MA and has developed a catheter based approach using laser energy with visualization focused on atrial fibrillation.Visit website
Developing a device for treating Dilated cardiomyopathy (DCM)which causes one third of congestive heart failure cases.Visit website
Cibiem (Formely Coridea NC2)
Cibiem (Formely Coridea NC2)
Cibiem is a seed stage device company which is focusing on exploring possible treatments for diastolic heart failure, refractory angina and end-stage renal disease.
CSA Medical the leading developer of novel Spray Cryotherapy devices that freeze and destroy unwanted tissue inside the body.Visit website
Direct Flow Medical
Direct flow Medical has developed a next generation aortic valve technology to compete in the Transcatheter Aortic Valve Replacement (TAVR) market.Visit website
EBR Systems is developing a wireless cardiac stimulation device (WiCS) to compete in the cardiac resynchronization therapy space for treatment of congestive heart failure.Visit website
Developing an implantable pulmonary artery pressure sensor to monitor hemodynamics and manage patient drug therapy and fluid volume status, to aid in the prevention of worsening heart failure hospitalizations.Visit website
Xmedica is a medical device Contract Developer (CD). The company is fully vertically integrated in device and systems design and development and has a business balanced across several sectors: professional/surgical devices; combination products; self-directed/consumer devices.Visit website
Argonaut developed a chemistry instrumentation for accelerated synthesis of novel organic molecules. Bought by Biotage after our exit.
Cardiac Support Systems
Cardiac Support Systems was an innovation factory company.
Cardiomind has developed an innovative stent and stent delivery system for small, difficult-to-access vessels.
Cerebral Vascular Applications
Cerebral Vascular Applications (TIF Company) has developed a set of minimally invasive tools for atrial appendage sealing for stroke prevention.
CHF is based in Brooklyn Park, MN and has developed a mechanical pump/filter system to remove excess fluid from patients with acute de-compensated congestive heart failure. The product has US 510k clearance and is CE marked for both in-patient hospital care and out-patient clinic use.
Confluent Surgical was a biomaterials for adhesion prevention and vascular embolics.
Eunoe was a treatment of neurological disorders through cerebrospinal fluid management (CSF).
Euro Dentalversand Holding
Euro was mail order dental consumables.
General Surgical Innovations
General Surgical Innovations is a minimally invasive approach to hernia repair and incontinence (purchased by United States Surgical).
Genosis has developed home use diagnostic devices to assess fertility in couples of childbearing age. Genosis products - Fertell, which provide both male and female tests, are available over the counter in the UK and the US and provide couples with the tools required to assess their fertility in the privacy of their homes.
Halscion is seed-stage company founded by The Innovation Factory which is developing a biomaterial for wound management.
Insulet is designing and developing products that provide superior treatment for people with diabetes. The Company's first commercial product is a wireless 3-day insulin pump.
LenSx Lasers, Inc
LenSx was initially backed by SVLS as a start-up company developing an integrated femtosecond laser system to perform phacolysis (for cataract lens extraction), alignment of premium intraocular lens (IOL) placement, and corneal incisions for treating astigmatism, all of which will be used during a single comprehensive cataract procedure.Visit website
MedNova was a device for interventional radiology and cardiology.
Micromass was a minimally invasive approach to hernia repair and incontinence (purchased by Waters).
MicroMed based in Houston, TX, has developed an implantable pump for use as a Left Ventricular Assist Device (LVAD) to aid the heart's pumping action in patients suffering from congestive heart failure.
MindFrame is a seed stage company formed out of Intersect Partners developing a novel mechanical device for the treatment of ischemic stroke.
Nexan was a remote telemonitoring devices.
NovaLign, based in Duluth, GA, is developing a minimally invasive implant for long bone fixation. Formerly known as OsteoLign.
Pelton & Crane
Pelton & Crane developed sterilization equipment.
Sirona Dental Systems
Sirona was a dental equipment manufacturer.
Healthcare Services and Digital Health
Healthcare services and digital health are transformational – they’re at the center of healthcare reform and cost containment. We seek growth equity opportunities in new services, delivery tools and healthcare IT.
AeroCare Holdings, Inc.
AeroCare is one of the largest providers of respiratory therapy products and durable medical equipment and services in the US.Visit website
Aligned Telehealth, Inc.
Aligned Telehealth is a provider of in-house psychiatric specialty physicians and turnkey telemedicine solutions to acute-care hospitals, emergency rooms, skilled nursing facilities and correctional institutions.Visit website
Centauri Health Solutions is a technology-centric company specializing in hosted software solutions, data-driven services, and data management designed specifically for risk adjustment and quality based revenue programs.Visit website
A full-service healthcare organization that has been revolutionizing the delivery of post-acute care to the frail elderly.Visit website
Jet Health is a full service Medicare-certified home health services company, providing skilled nursing, therapy, social work, and home health aide services.Visit website
Maestro Healthcare provides best-in-class master data modeling and data quality controls, and an accelerated deployment path for rapid time-to-value while minimizing cost, resources, and risk. Maestro Healthcare components are modular in design, allowing payers and providers to implement only those components that directly meet their business needs and requirements.Visit website
Nordic Consulting Partners
Nordic Consulting is a leading Healthcare IT (HIT) consulting firm focused exclusively on the implementation of Epic systems at healthcare providers.Visit website
Schweiger Dermatology is a comprehensive dermatology practice with multiple locations throughout New York City, including: Midtown, Midtown West, Financial District and Flatiron District.Visit website
Spectrum Professional Services
Spectrum Professional Services is building a suite of services to provide to nursing homes and other long term care facilities on an outsourced basis. The initial platform acquisition is focused on the contract rehabilitation therapy area.Visit website
SUN Behavioral Health
SUN Behavioral Health operates freestanding psychiatric hospitals where a substantial unmet need for acute psychiatric services existsVisit website
An urgent care company focused on treating patients. Clinics offer you the convenience and expertise to treat non life-threatening illnesses or injuries while saving you time and money. Formerly known as Urgent Care.Visit website
US Renal Care
US Renal Care(USRC) based in Dallas, TX, provides dialysis services to patients with end stage renal disease (ESRD) through the ownership and management of freestanding dialysis clinics. The company partners with local nephrologists in secondary markets underserved by dialysis consolidators.Visit website
Allegiance Hospice Group
Allegiance Hospice is based in Lowell, MA, focused on providing hospice services to patients primarily in long- term care facilities within the New England market.
AllianceCare, based in Boynton Beach, FL, is a senior healthcare provider of Private Duty Home Care, Skilled Home Health, Physician Housecalls and Rehab. The Company currently offers services through 17 branch offices in 3 states.
Aptiv is a Contract Research Organization (CRO) developing a global provider of outsourced clinical monitoring, data management and other related services for biotechnology and pharmaceutical companies conducting Phase II-IV clinical trials. (Formerly known as Averion International Corp. and CR, LLC).Visit website
Cadent is based in Carlstadt, NJ and has developed proprietary computer aided design (CAD/CAM) applications for the orthodontist and dental markets, which are deployed via a web-based service model on a pay per use basis.
Coral was a provision of blood handling services to hospitals.
CRI Worldwide, founded in 2000, is a CNS focused network of clinical research facilities conducting phase I-III trials (mostly inpatient studies). CRI operates research units in partnership with local area hospitals providing "flexible" bed arrangements and yet they are able to use a central IRB.Visit website
EasyChem was a B2B chemical e-commerce electronic marketplace.
eMed Delivered medical images over the internet.
Euro was mail order dental consumables.
Expand Sante was a French pharmaceutical contract sales organisation.
Heritage Health Systems
Heritage was a physician practice.
IHG was a preferred provider organization. (Formerly known as Interplan).
ISG Holdings is a business offering workers compensation scheme outsourcing by businesses with US operations.
JC Nationwide was a physician recruitment agency.
MDeverywhere based in Hauppauge, NY with operations in New Dehli, India, is an outsourced physician billing company.
OMS Foundations was an oral maxillofacial physician practice management.
Patient Care based in Orange, NJ, is one of the largest independent home health agencies.
Phase Forward was a web-based information technology for clinical trials management.
Physicians Dialysis was a consolidator of renal dialysis centers (Purchased by DaVita).
Quick Study Radiol
QSR based in St. Louis, MO, sells comprehensive digital imaging services to community hospitals and imaging centers. The company integrates, manages and supports clinical and data systems for customers with a focus on underserved small and secondary city locations.
Socios Mayores en Salud
Socios Mayores en Salud provides health insurance to seniors in Puerto Rico through a Medicare Advantage plan that operates similar to traditional managed care organizations.
The Corner Pharmacy
An owner and operator of hospital-based retail pharmacies through joint ventures with hospital systems.
TLC Vision was a service provider for laser-based ophthalmic surgery. Formerly known as Laservision.
Vintage BioMed was a capital equipment leasing and maintenance company.
Vitalize Consulting Solutions
Vitalize Consulting Solutions, Inc. provides the highest quality clinical and business solutions to healthcare organizations across the United States and Canada. Their main focus is in the areas of application implementation and enhancement, process optimization, interfaces, project management, technology and integration, training and knowledge transfer.Visit website