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Dominic Smethurst

Venture Partner

Dom joined SV as a Venture Partner in 2023 and runs his own consulting business liaising principally around clinical development, fundraising, medical affairs and translational medicine activities for small and medium sized immunology and oncology companies.

Most recently, Dom served as Chief Medical Officer at SV portfolio company Bicycle Therapeutics (Nasdaq:BCYC) taking three compounds through early and into late-stage development, achieving profound insights into a new field of constrained peptide therapeutics. Dom supported the Company in raising over $300m.

Dom has taken three biotech companies (Immunocore, Adaptimmune and BCYC) to unicorn status through multiple successful partnering and investor discussions. He has also helped propel clinical development plans that outpaced wall street predictions often with outstanding value-creation effects.

Outside of SV, Dom holds an advisor role for a children’s medical charity; works as a Rugby Coach/Physician for Wasps Rugby Football Union club Under 14s side and is a keen cook.

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